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	<title>DermBytes</title>
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	<link>http://www.dermbytes.com</link>
	<description>Dermatology blog &#124; all things dermatology and skin</description>
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		<title>Loxosceles reclusa&#8230;? A mouthful meaning&#8230;</title>
		<link>http://www.dermbytes.com/loxosceles-reclusa-a-mouthful-meaning/</link>
		<comments>http://www.dermbytes.com/loxosceles-reclusa-a-mouthful-meaning/#comments</comments>
		<pubDate>Fri, 24 May 2013 02:37:51 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[brown recluse]]></category>
		<category><![CDATA[loxosceles reclusa]]></category>
		<category><![CDATA[sphingomyelinase D]]></category>
		<category><![CDATA[spider bite]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=786</guid>
		<description><![CDATA[<p>Brown recluse spider.  In this third post on spiders (previous ones on the <a href="http://www.dermbytes.com/when-tarantulas-attack/">tarantula </a>and <a href="http://www.dermbytes.com/when-the-black-widow-attacks/">black widow spider</a> here), we&#8217;ll talk about the brown recluse spider.  Like the black widow spider, the brown recluse spider also has a unique marking on its body.  It&#8217;s a tan spider with a violin-shaped marking on its [...]]]></description>
				<content:encoded><![CDATA[<div id="attachment_787" class="wp-caption alignleft" style="width: 160px"><a href="http://www.dermbytes.com/loxosceles-reclusa-a-mouthful-meaning/brown_recluse_spider-loxosceles_reclusa/" rel="attachment wp-att-787"><img class="size-thumbnail wp-image-787" alt="Note the brown violin marking on the spider" src="http://www.dermbytes.com/wp-content/uploads/2013/05/Brown_recluse_spider-Loxosceles_reclusa-150x150.jpg" width="150" height="150" /></a><p class="wp-caption-text">Note the brown violin marking on the spider</p></div>
<p><strong>Brown recluse spider</strong>.  In this third post on spiders (previous ones on the <a href="http://www.dermbytes.com/when-tarantulas-attack/">tarantula </a>and <a href="http://www.dermbytes.com/when-the-black-widow-attacks/">black widow spider</a> here), we&#8217;ll talk about the brown recluse spider.  Like the black widow spider, the brown recluse spider also has a unique marking on its body.  It&#8217;s a tan spider with a violin-shaped marking on its belly.  That&#8217;s where the cuteness stops for me though.</p>
<p>The brown recluse spider bite is another serious spider bite.  While the initial bite can be completely painless, it can be followed with a &#8220;red, white, and blue sign&#8221; where the skin initially becomes inflamed, then white from lack of blood flow, and then blue as the tissues suffocate without blood and oxygen.  The skin can break down causing <em>necrosis </em>(death of the skin).  Additionally, the toxin that the brown recluse injects, <em>sphingomyelinase D (a phospholipase)</em>, can lead to destruction of your red blood cells, causing a condition called <em>hemolytic anemia</em>.  It can also cause destruction of another cell call the platelet (leading to <em>thrombocytopenia</em>).  Bites may be especially serious in kids.  In short, suspect a brown recluse spider bite? It can lead to badness.  Get medical help!</p>
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		<title>When the black widow attacks&#8230;</title>
		<link>http://www.dermbytes.com/when-the-black-widow-attacks/</link>
		<comments>http://www.dermbytes.com/when-the-black-widow-attacks/#comments</comments>
		<pubDate>Fri, 24 May 2013 02:23:03 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[black widow spider]]></category>
		<category><![CDATA[latrodectus matans]]></category>
		<category><![CDATA[latrotoxin]]></category>
		<category><![CDATA[spider bite]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=779</guid>
		<description><![CDATA[<p>With a bold bright red hourglass on its belly against a shiny black background, the black widow spider is all business.  Thus, when the black widow spider attacks&#8230; well, you better hope it doesn&#8217;t!</p> <p>As a quick aside, how did the black widow spider get its name?  The female black widow spider was reported to [...]]]></description>
				<content:encoded><![CDATA[<div id="attachment_780" class="wp-caption alignleft" style="width: 160px"><a href="http://www.dermbytes.com/when-the-black-widow-attacks/black-widow-spider/" rel="attachment wp-att-780"><img class="size-thumbnail wp-image-780" alt="Image from Wikipedia user Trachemys" src="http://www.dermbytes.com/wp-content/uploads/2013/05/Black-Widow-spider-150x150.jpg" width="150" height="150" /></a><p class="wp-caption-text">Image from Wikipedia user Trachemys</p></div>
<p>With a bold bright red hourglass on its belly against a shiny black background, the black widow spider is all business.  Thus, when the black widow spider attacks&#8230; well, you better hope it doesn&#8217;t!</p>
<p>As a quick aside, how did the black widow spider get its name?  The female black widow spider was reported to eat its male mate after mating.  In reality, it does not always do this.</p>
<p>When folks think of spider bites, they often imagine deadly spider bites.  In reality, the majority of spider bites are not life threatening.  However, the black widow spider bite is one of the more serious spider bites.</p>
<p>The black widow spider, also formidably known as <em>Latrodectus mactans</em>, can release a toxin called <em>alpha-latrotoxin</em>.  This causes your nerve cells (aka neurons) to depolarize.  Bites can lead to pain and swelling at the site of the bite but also fever, chills, nausea, vomiting, muscle pain, cramps, spasms and abdominal pain.  Needless to say, these are indications to get medical help.</p>
<p>&nbsp;</p>
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		<title>When tarantulas attack&#8230;</title>
		<link>http://www.dermbytes.com/when-tarantulas-attack/</link>
		<comments>http://www.dermbytes.com/when-tarantulas-attack/#comments</comments>
		<pubDate>Fri, 24 May 2013 01:54:41 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[ophthalmia nodosa]]></category>
		<category><![CDATA[spider]]></category>
		<category><![CDATA[spider bite]]></category>
		<category><![CDATA[tarantula]]></category>
		<category><![CDATA[urticaria]]></category>
		<category><![CDATA[wheal hive]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=771</guid>
		<description><![CDATA[<p></p> <p>People often come into the clinic worried about spider bites.  While the majority of these concerns turn out not to be spider bites, it does raise the question of what sorts of medical conditions spiders can cause.  In the United States, tarantulas (shown on the left) are one type of spider that may be found [...]]]></description>
				<content:encoded><![CDATA[<p><img class="alignleft size-thumbnail wp-image-772" alt="Tarantula" src="http://www.dermbytes.com/wp-content/uploads/2013/05/Tarantula-150x150.jpg" width="150" height="150" /></p>
<p>People often come into the clinic worried about spider bites.  While the majority of these concerns turn out not to be spider bites, it does raise the question of what sorts of medical conditions spiders can cause.  In the United States, <em>tarantulas </em>(shown on the left) are one type of spider that may be found in the wild and as pets.  While tarantulas can bite, a more common form of defense is for the tarantula to throw its hairs at a predator (e.g. at you if it thinks you&#8217;re going to attack it!)  These hairs have little barbs and are urticating, meaning they can cause <em style="line-height: 1.6em;">urticaria </em>(a fancy word for hives or wheals).</p>
<p>These little barbed hairs can lodge in the skin and cause wheals or, they can also lodge into the eye.  When they lodge in the eye, these tarantula hairs cause a condition called <em>ophthalmia nodosa</em>.  These barbs in the eye cause the eye to get inflamed and could actually lead to vision loss if severe enough.</p>
<p>Needless to say, if you believe you&#8217;ve been attacked by a tarantula, you should probably get checked out.  More on other spiders (e.g. black widow, brown recluse, etc.) in future posts.</p>
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		<title>How does ultraviolet (UV) light cause tanning of our skin?</title>
		<link>http://www.dermbytes.com/how-does-ultraviolet-uv-light-cause-tanning-of-our-skin/</link>
		<comments>http://www.dermbytes.com/how-does-ultraviolet-uv-light-cause-tanning-of-our-skin/#comments</comments>
		<pubDate>Sun, 07 Apr 2013 13:00:30 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[melanin]]></category>
		<category><![CDATA[tan]]></category>
		<category><![CDATA[ultraviolet]]></category>
		<category><![CDATA[UV]]></category>
		<category><![CDATA[UVA]]></category>
		<category><![CDATA[UVB]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=760</guid>
		<description><![CDATA[<p><a href="http://www.dermbytes.com/?attachment_id=761" rel="attachment wp-att-761"></a>In a continuation on the theme of ultraviolet (UV) light, we answer the question of how UV light causes tanning or darkening of our skin.   The answer is that there are multiple methods by which tanning occurs.</p> <p>Depending on your baseline skin type, you  may have noticed that after being out [...]]]></description>
				<content:encoded><![CDATA[<p><a href="http://www.dermbytes.com/?attachment_id=761" rel="attachment wp-att-761"><img class="alignleft size-thumbnail wp-image-761" alt="Tanned arm" src="http://www.dermbytes.com/wp-content/uploads/2013/04/Tanned-arm-150x150.jpg" width="150" height="150" /></a>In a continuation on the theme of ultraviolet (UV) light, we answer the question of how UV light causes tanning or darkening of our skin.   The answer is that there are multiple methods by which tanning occurs.</p>
<p>Depending on your baseline skin type, you  may have noticed that after being out in the sun, your skin becomes tanned or darker (if you&#8217;re very fair-skinned, you may not tan at all, but rather, just burn).  You may have noticed this change in your skin tone hours after your sun exposure, or perhaps days after.</p>
<p>Tanning/darkening occurs via two methods and thus can occur immediately as well as in a delayed form.</p>
<p>1) In immediate tanning, the darkening occurs <em>hours</em> after the exposure to ultraviolet light.  The trigger is ultraviolet-A (UVA) light.  The melanin (pigment giving our skin color) which is already sitting around in your skin cells becomes oxidized.  Melanosomes (which are sacs of melanin in our cells) also get redistributed.  These effects occur relatively quickly and the tan can be seen within hours.  Note that in this form of tanning, there is no protective effect against additional UV exposure.</p>
<p>2) In delayed tanning, new melanin is made by your cells in a process called melanogenesis.  Since it takes time for your cells to make melanin, the tan is not evident until <em>48-72 hours</em> after exposure.  This process is triggered by ultraviolet-B (UVB) light.</p>
<p>Need a review on the difference between UVA and UVB and wavelengths of light? See the previous <a href="http://www.dermbytes.com/what-is-ultraviolet-light/">DermBytes post</a> on this topic.</p>
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		<title>What is ultraviolet light?</title>
		<link>http://www.dermbytes.com/what-is-ultraviolet-light/</link>
		<comments>http://www.dermbytes.com/what-is-ultraviolet-light/#comments</comments>
		<pubDate>Sun, 07 Apr 2013 12:23:49 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[Skin Cancer]]></category>
		<category><![CDATA[skin cancer]]></category>
		<category><![CDATA[sunscreen]]></category>
		<category><![CDATA[ultraviolet]]></category>
		<category><![CDATA[UV]]></category>
		<category><![CDATA[UVA]]></category>
		<category><![CDATA[UVB]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=756</guid>
		<description><![CDATA[<p><a href="http://www.dermbytes.com/cruising-in-the-caribbean-beware-the-seabather%e2%80%99s-eruption/bahamas_beach/" rel="attachment wp-att-73"></a>What is ultraviolet (UV) light?  Ultraviolet light is made of up light waves of a certain wavelength.  What does that mean?  Well, I think back to grade school where we learned about different wavelengths of light.  Certain wavelengths would form certain colors of light. e.g. in a rainbow, each color reflects a [...]]]></description>
				<content:encoded><![CDATA[<p><em><a href="http://www.dermbytes.com/cruising-in-the-caribbean-beware-the-seabather%e2%80%99s-eruption/bahamas_beach/" rel="attachment wp-att-73"><img class="alignleft size-thumbnail wp-image-73" alt="Bahamas_beach" src="http://www.dermbytes.com/wp-content/uploads/2011/08/Bahamas_beach-150x150.jpg" width="150" height="150" /></a>What is ultraviolet (UV) light?</em>  Ultraviolet light is made of up light waves of a certain wavelength.  What does that mean?  Well, I think back to grade school where we learned about different wavelengths of light.  Certain wavelengths would form certain colors of light. e.g. in a rainbow, each color reflects a different wavelength of light (recall the mnemonic of ROYGBIV for the colors of the rainbow? red, orange, yellow, green, blue, indigo, and violet).  However, these colors of light were part of visible light. This is light that we can see with our eyes.</p>
<p>However, there&#8217;s light that we can&#8217;t see as well.  We can&#8217;t see ultraviolet light.</p>
<p><em>So what does ultraviolet light have to do with the skin?</em> (After all, DermBytes is a blog about all things skin.)  Well, ultraviolet light can cause damage to the DNA of our cells and can also make our immune system less effective.  UV light can lead to sunburns, cause darkening or tanning of the skin, and lead to increased risk of skin cancer. In some people, UV light can also lead to various rashes. In others, patients may find that the light helps their skin rash (e.g. psoriasis).</p>
<p>Because of the potential deleterious effects of UV on the skin and its potential to lead to skin cancer, dermatologists recommend using sunscreen.  Remember from our <a href="http://www.dermbytes.com/what-is-spf-spf-sunburn-protection-factor/">previous post</a> that we should choose a sunscreen that protects against both UVA and UVB.  UVA and UVB simply refers to different sets of wavelengths. (Specifically, UVA includes wavelengths of 315-400 nm and UVB includes wavelengths of 290-315 nm).</p>
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		<title>What is Athlete&#8217;s Foot?</title>
		<link>http://www.dermbytes.com/what-is-athletes-foot/</link>
		<comments>http://www.dermbytes.com/what-is-athletes-foot/#comments</comments>
		<pubDate>Sat, 06 Apr 2013 06:59:59 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[athlete's foot]]></category>
		<category><![CDATA[foot fungus]]></category>
		<category><![CDATA[Lamisil]]></category>
		<category><![CDATA[terbinafine]]></category>
		<category><![CDATA[tinea pedis]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=751</guid>
		<description><![CDATA[<p>Athlete&#8217;s foot is a common skin complaint and is also commonly known as &#8220;foot fungus&#8221; and ringworm of the foot (although it&#8217;s not caused by a worm!) It is more formally known as tinea pedis.  The name &#8220;Athlete&#8217;s Foot,&#8221; however, gives us a sense of conditions that predispose to getting this condition. In athlete&#8217;s foot, [...]]]></description>
				<content:encoded><![CDATA[<div id="attachment_752" class="wp-caption alignleft" style="width: 160px"><a href="http://www.dermbytes.com/what-is-athletes-foot/tinea-pedis/" rel="attachment wp-att-752"><img class="size-thumbnail wp-image-752" alt="Image taken by Dr James Heilman" src="http://www.dermbytes.com/wp-content/uploads/2013/04/tinea-pedis-150x150.jpg" width="150" height="150" /></a><p class="wp-caption-text">Image taken by Dr James Heilman</p></div>
<p>Athlete&#8217;s foot is a common skin complaint and is also commonly known as &#8220;foot fungus&#8221; and ringworm of the foot (although it&#8217;s not caused by a worm!) It is more formally known as <em>tinea pedis</em>.  The name &#8220;Athlete&#8217;s Foot,&#8221; however, gives us a sense of conditions that predispose to getting this condition. In athlete&#8217;s foot, the skin is infected by a fungus that likes the surface of the skin. This fungus also favors moist conditions and you can pick it up at the gym, poolside, communal showers, contaminated shoes, etc.  One can thus think of the athlete who walks around barefoot in the communal gym &amp; shower area, picking up fungus on the feet.  Afterwards, the feet are then stuffed into shoes, where the fungus thrives in a dark damp environment.</p>
<p><em>So what does athlete&#8217;s foot look like?</em>  You may notice some scaling or redness between the toes or on the bottom of your feet.</p>
<p><em>What does it feel like?</em> Athlete&#8217;s foot may be asymptomatic, or there can be associated itch.</p>
<p><em>And what should you do if you have athlete&#8217;s foot?  </em>Keep the feet dry.  While athlete&#8217;s foot can go away on its own by keeping the feet dry and changing shoes, there are plenty of good over the counter creams to help it along.  The generic name for one cream that is frequently used is terbinafine (e.g. Lamisil) and this can be used twice a day. Of course, if you&#8217;re not sure whether you have foot fungus or something else, have it checked out. This is an easy diagnosis for a dermatologist or podiatrist to make.</p>
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		<title>Cupping</title>
		<link>http://www.dermbytes.com/cupping/</link>
		<comments>http://www.dermbytes.com/cupping/#comments</comments>
		<pubDate>Tue, 19 Mar 2013 19:21:05 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[alternative medicine]]></category>
		<category><![CDATA[cupping]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=735</guid>
		<description><![CDATA[<p>Growing up, my mom had told me the story of a kid whose parents practiced cupping on him.  Turns out that bruises which were left behind from the cuping and these bruises were noticed at school.  The parents were called in to investigate potential child abuse!</p> <p>So what is this practice of cupping? (Does it [...]]]></description>
				<content:encoded><![CDATA[<div id="attachment_737" class="wp-caption alignleft" style="width: 160px"><a href="http://www.dermbytes.com/cupping/fire_cupping/" rel="attachment wp-att-737"><img class="size-thumbnail wp-image-737" alt="Photo from Wikipedia, author Alanna Ralph" src="http://www.dermbytes.com/wp-content/uploads/2013/03/Fire_Cupping-150x150.jpg" width="150" height="150" /></a><p class="wp-caption-text">Photo from Wikipedia, author Alanna Ralph</p></div>
<p>Growing up, my mom had told me the story of a kid whose parents practiced cupping on him.  Turns out that bruises which were left behind from the cuping and these bruises were noticed at school.  The parents were called in to investigate potential child abuse!</p>
<p>So what is this practice of cupping? (Does it involve a cup?)</p>
<p>Cupping is an alternative medicine practice most commonly seen in Eastern Asian countries such as China.  Suction via &#8220;cups&#8221; placed on certain areas (often the back) is thought to mobilize important components such as blood in the body.  Sometimes, this suction is created via a pump, and other times by heating the air in the cup before placement onto the body.  (Remember from middle school and high school that as a gas cools, it compresses, so then you get suction.)  The cups are then removed after a period of time.  Sometimes, bruising is left behind but not always.</p>
<p>I&#8217;ve actually tried this cupping procedure before where the cups were heated before placement.  They did feel hot when placed, but then cooled down.  I could feel the skin being sucked into the cups.  All in all, it was not terribly uncomfortable.</p>
<p>I&#8217;m curious, how many of you have heard of cupping, had cupping, or have had friends who have had cupping?</p>
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		<title>Candle in your ear?</title>
		<link>http://www.dermbytes.com/candle-in-your-ear-learn-about-ear-candling/</link>
		<comments>http://www.dermbytes.com/candle-in-your-ear-learn-about-ear-candling/#comments</comments>
		<pubDate>Mon, 18 Mar 2013 20:35:09 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[ear candling]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=726</guid>
		<description><![CDATA[<p>Years ago, a relative of mine introduced me to the practice known as ear candling.  I didn&#8217;t have it tried on myself, but she was keen on trying it on an elder relative.</p> <p>First, the idea of putting a lit candle anywhere near the face let alone inside the ear seems a little scary to [...]]]></description>
				<content:encoded><![CDATA[<div id="attachment_729" class="wp-caption alignleft" style="width: 160px"><a href="http://www.dermbytes.com/candle-in-your-ear-learn-about-ear-candling/ear-candling/" rel="attachment wp-att-729"><img class="size-thumbnail wp-image-729" alt="Ear candling. Debris accumulates from the lighting of the candle." src="http://www.dermbytes.com/wp-content/uploads/2013/03/Ear-candling-150x150.jpg" width="150" height="150" /></a><p class="wp-caption-text">Ear candling. Debris accumulates from the lighting of the candle.</p></div>
<p>Years ago, a relative of mine introduced me to the practice known as <em>ear candling</em>.  I didn&#8217;t have it tried on myself, but she was keen on trying it on an elder relative.</p>
<p>First, the idea of putting a lit candle anywhere near the face let alone inside the ear seems a little scary to me.  As it should to you too.  This practice is one that is practiced by people with the hope of improving health and sometimes to remove ear wax.  However, it is likely ineffective for both.  A hollow wax candle or cylinder of waxed cloth is lit and the non-lit end is placed in the ear of the individual.  The ear being treated is facing upwards.  Often, the candle is placed through a paper plate with a hole cut in it in order to catch any dripping wax or ash.</p>
<p>Studies have not shown any health benefit and in fact, trauma to the ear has occurred during this procedure.  The debris that is thought to be from inside the ear is debris that gathers just from lighting of the candle (whether or not it is placed in the ear or not.)  So just as your doctor warns you again sticking a qtip into your ear, don&#8217;t go sticking a candle in your ear!</p>
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		<item>
		<title>Name that syndrome: Can&#8217;t see, can&#8217;t pee, can&#8217;t climb a tree</title>
		<link>http://www.dermbytes.com/name-that-syndrome-cant-see-cant-pee-cant-climb-a-tree/</link>
		<comments>http://www.dermbytes.com/name-that-syndrome-cant-see-cant-pee-cant-climb-a-tree/#comments</comments>
		<pubDate>Mon, 11 Mar 2013 22:43:53 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Patient Education]]></category>
		<category><![CDATA[arthritis]]></category>
		<category><![CDATA[Chlamydia]]></category>
		<category><![CDATA[circinate balanitis]]></category>
		<category><![CDATA[conjunctivitis]]></category>
		<category><![CDATA[keratoderma blenorrhagicum]]></category>
		<category><![CDATA[Reiter's Syndrome]]></category>
		<category><![CDATA[Salmonella]]></category>
		<category><![CDATA[Shigella]]></category>
		<category><![CDATA[urethritis]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=719</guid>
		<description><![CDATA[<p>So do you know which syndrome goes with the findings of conjunctivitis (inflammation of the eyes), urethritis (inflammation of the urethra), and arthritis (inflammation of the joints)? An additional clue is the photo on the left of keratoderma blenorrhagicum, the fancy name for these red- brown plaques, bumps and pus bumps that can occur on [...]]]></description>
				<content:encoded><![CDATA[<div id="attachment_720" class="wp-caption alignleft" style="width: 160px"><a href="http://www.dermbytes.com/name-that-syndrome-cant-see-cant-pee-cant-climb-a-tree/keratoderma-blenorrhagicum-reiters-feet/" rel="attachment wp-att-720"><img class="size-thumbnail wp-image-720" alt="Findings of the feed associated with Reiter's Syndrome" src="http://www.dermbytes.com/wp-content/uploads/2013/03/Keratoderma-blenorrhagicum-Reiters-Feet-150x150.jpg" width="150" height="150" /></a><p class="wp-caption-text">Findings of the feet associated with Reiter&#8217;s Syndrome</p></div>
<p>So do you know which syndrome goes with the findings of conjunctivitis (inflammation of the eyes), urethritis (inflammation of the urethra), and arthritis (inflammation of the joints)? An additional clue is the photo on the left of <em>keratoderma blenorrhagicum</em>, the fancy name for these red- brown plaques, bumps and pus bumps that can occur on the soles of the feet.  Additionally, another finding in men are circular red spots on the penis called <em>circinate balanitis</em> which is almost diagnostic of this condition.</p>
<p>We&#8217;re talking about <strong>Reiter&#8217;s Syndrome</strong>.  Reiter&#8217;s Syndrome classically is described as a triad of conjunctivitis (can&#8217;t see), urethritis (can&#8217;t pee), and arthritis (can&#8217;t climb a tree).  It often develops as a reaction to an infection such as <em>Chlamydia</em> in the urethra or cervix, or gastrointestinal infections from <em>Campylobacter, Shigella, Salmonella, Yersinia</em> or <em>Ureaplasma</em>.  Interestingly, there&#8217;s also a genetic predisposition to getting this.  Individuals who get this are more likely to have a genetic factor called HLA-B27.</p>
<p>So what to do if you have Reiter&#8217;s Syndrome? Well, hopefully you made your way to a doctor already who made the diagnosis.  Your physician will treat the underlying infection if one is found, and will manage the symptoms that you have individually.</p>
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		<title>Highlights from the AAD 2013, Miami: Advances in Melanoma</title>
		<link>http://www.dermbytes.com/highlights-from-the-aad-2013-miami-advances-in-melanoma/</link>
		<comments>http://www.dermbytes.com/highlights-from-the-aad-2013-miami-advances-in-melanoma/#comments</comments>
		<pubDate>Tue, 05 Mar 2013 20:51:00 +0000</pubDate>
		<dc:creator>Susan Huang MD</dc:creator>
				<category><![CDATA[Meeting Updates]]></category>
		<category><![CDATA[Melanoma]]></category>
		<category><![CDATA[Skin Cancer]]></category>
		<category><![CDATA[AAD]]></category>
		<category><![CDATA[dabrafenib]]></category>
		<category><![CDATA[melanoma]]></category>
		<category><![CDATA[oncogene]]></category>
		<category><![CDATA[proto-oncogene]]></category>
		<category><![CDATA[skin cancer]]></category>
		<category><![CDATA[tramatenib]]></category>
		<category><![CDATA[tumor suppressor]]></category>
		<category><![CDATA[vemurafenib]]></category>

		<guid isPermaLink="false">http://www.dermbytes.com/?p=710</guid>
		<description><![CDATA[<p>An exciting talk from this year&#8217;s American Academy of Dermatology Meeting (AAD 2013) in Miami was the annual Marion B. Sulzberger Memorial Award and Lectureship given by Dr. Hensin Tsao.  Dr. Tsao talked about &#8220;Melanoma and Its Metaphors,&#8221; drawing parallels between the machinery behind melanoma to the machinery behind cars.  While problems can arise with [...]]]></description>
				<content:encoded><![CDATA[<p>An exciting talk from this year&#8217;s American Academy of Dermatology Meeting (AAD 2013) in Miami was the annual Marion B. Sulzberger Memorial Award and Lectureship given by Dr. Hensin Tsao.  Dr. Tsao talked about &#8220;Melanoma and Its Metaphors,&#8221; drawing parallels between the machinery behind melanoma to the machinery behind cars.  While problems can arise with cars, so can the biological machinery that drives cells to go out of control and develop into melanoma.  Dr. Tsao discussed tumor suppressor and proto-oncogenes.  Likening them to faulty brake systems, Dr. Tsao discussed how tumor suppressor genes are like the brakes in cells, and when messed up, the cell keeps going, dividing out of control.  On the other hand, if the accelerator of the car gets stuck in the down position, the car keeps going as well. Proto-oncogenes, or oncogenes, are accelerators of melanoma.</p>
<p>In the realm of melanoma therapy, we&#8217;ve made some great strides in directed therapy.  Among these are the drugs that target a very specific mutation that 60% of melanomas have (the V600E mutation).  These are drugs like <em>vemurafenib</em> and <em>dabrafenib</em>.  Although some of the tumors then find ways around these drugs when given alone, researchers and physicians have then added an additional drug, <em>tramatenib</em> (a MEK inhibitor) to the cocktail.  Two hits against the melanoma!  And there&#8217;s even more exciting stuff to come.</p>
<p>In short, in these past few years, we have seen major advances in melanoma therapy and I hope that with the direction we&#8217;re going, we&#8217;ll be able to put a permanent halt to melanoma!</p>
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